abstract：BACKGROUND:The incidence of bloodborne AIDS and the total incidence of AIDS in various areas of the United States are strongly correlated. STUDY DESIGN AND METHODS:To determine whether the same held true for Western Europe, data for 1985 through 1993 from the World Health Organization's European Non-Aggregate AIDS Dat...

journal_title：Transfusion

authors： Dal Maso L,Franceschi S,Lo Re A,De Angelis V,La Vecchia C

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Cellular blood components are irradiated to prevent graft-versus-host disease in transfusion recipients at risk for this syndrome. Because gamma radiation can result in the production of reactive oxygen species, the role of reactive oxygen species was investigated in radiation-induced red cell damage. STUDY...

journal_title：Transfusion

authors： Anand AJ,Dzik WH,Imam A,Sadrzadeh SM

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Human T-cell lymphoma/leukemia viruses types I and II (HTLV-I and HTLV-II) are related exogenous human retroviruses. The former is definitely pathogenic while disease association with the latter is unclear. There are two subtypes of HTLV-II, A and B. Currently, enzyme-linked immunosorbent assays (ELISAs) bas...

journal_title：Transfusion

authors： Poiesz BJ,Dube S,Jones B,Bryz-Gornia V,Dean MT,Spicer T,Hengst J,Sayre K,Esteban E,Ferrer JF

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Although infrequent, episodes of transfusion-associated bacterial sepsis may lead to serious outcomes or death and therefore are of concern. This study evaluates the sensitivity of three surrogate tests for the presence of bacteria in platelet concentrates: cessation of swirling, low extracellular pH, and lo...

journal_title：Transfusion

authors： Wagner SJ,Robinette D

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Allogeneic blood cell transplantation is a new alternative to bone marrow transplantation. Preliminary data suggest that granulocyte-colony-stimulating factor (G-CSF)-mobilized peripheral blood progenitor cells from normal donors can provide rapid hematopoietic engraftment without significant increases in tr...

journal_title：Transfusion

authors： Weinthal JA,Nemunaitis JJ,Aston S,Magsamen MJ,Rosenfeld CS

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Blood components are often given prophylactically before the placement of invasive lines in patients with coagulation defects. Little, however, is known about the epidemiology of defects in these patients. The purpose of this study is to ascertain what proportion of intensive care patients who receive invasi...

journal_title：Transfusion

authors： DeLoughery TG,Liebler JM,Simonds V,Goodnight SH

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:It is important to compare the incidence of bacterial contamination of components collected from the peripheral blood or bone marrow (BM), as well as of components processed with or without cell selection or depletion, and to evaluate the sequelae of such contamination. STUDY DESIGN AND METHODS:Bacterial co...

journal_title：Transfusion

authors： Webb IJ,Coral FS,Andersen JW,Elias AD,Finberg RW,Nadler LM,Ritz J,Anderson KC

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Passive immunotherapy in human immunodeficiency virus (HIV) infection is based on transfusions of plasma that is rich in HIV antibodies. STUDY DESIGN AND METHODS:To verify whether the clearance of transfused antibodies will maintain an elevated titer of specific antibodies between biweekly transfusions of p...

journal_title：Transfusion

authors： Lefrère JJ,Roudot-Thoraval F,Vittecoq D,Heshmati F,Audat F,Lerable J,Reed D,Petit JC,Burghoffer B,Morand-Joubert L

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Volume replacement could allow the safe collection of twice the normal amount of red cells in a standard donation. Studies in small numbers of donors have shown that a temporary decrease in red cell mass is well tolerated when donors give twice the usual amount (170-225 mL) of red cells in a standard 405- to...

journal_title：Transfusion

authors： Smith KJ,James DS,Hunt WC,McDonough W,Quintana R

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Absolute counts of CD4+ T-lymphocytes are used in the management of patients with human immunodeficiency virus infection. Low absolute counts of CD3+CD4+ cells have also been observed in healthy people--a phenomenon called idiopathic CD4 lymphocytopenia. It is common practice for normal ranges for lymphocyte...

journal_title：Transfusion

authors： Bryant JA,Wylie BR,Yuan FF,Ribeiro A,Thomson AR,Cooley MA,Fletcher A

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:The major cause of fetal hemolytic disease is maternal immunization to D in D-incompatible pregnancies. To prevent complications, D-incompatible pregnancies are monitored for the level of maternal anti-D. At present, the monitoring of anti-D levels is performed by the indirect antiglobulin test complemented ...

journal_title：Transfusion

authors： Christensson M,Bremme K,Shanwell A,Westgren M,Christensson B

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Platelets contain several mediators, belonging to a family of proinflammatory cytokines named chemokines, that are stored in the organelles. Release and accumulation of these chemokines during storage of platelet concentrates (PCs) might be responsible for nonhemolytic transfusion reactions. STUDY DESIGN AN...

journal_title：Transfusion

authors： Bubel S,Wilhelm D,Entelmann M,Kirchner H,Klüter H

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Patients with severe combined immunodeficiency (SCID) treated with allogeneic bone marrow transplantation often receive a milder conditioning regimen than patients who undergo transplantation for hematologic malignancy, and they regularly retain circulating white cells of host origin. The origin of circulati...

journal_title：Transfusion

authors： Brady KA,Cowan MJ,Leavitt AD

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Treatment of hemophilia patients with recombinant factor VIII concentrates has not previously been associated with anaphylaxis. STUDY DESIGN AND METHODS:A 5-week-old boy with severe hemophilia A developed dyspnea, cyanosis, hypotension, and a diffuse urticarial rash following treatment with a recombinant fa...

journal_title：Transfusion

authors： Shopnick RI,Kazemi M,Brettler DB,Buckwalter C,Yang L,Bray G,Gomperts ED

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to develop human immunodeficiency virus (HIV) infection donation deferral criteria for blood donors in an HIV-epidemic area of northern Thailand, where the predominant means of transmission of HIV is through heterosexual contact. STUDY DESIGN AND METHODS:In a preliminary study,...

journal_title：Transfusion

authors： Sawanpanyalert P,Uthaivoravit W,Yanai H,Limpakarnjanarat K,Mastro TD,Nelson KE

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Posttransfusion graft-versus-host disease (PT-GVHD) is underdiagnosed and underreported. Risk factors predisposing to PT-GVHD in newborn recipients, the clinical manifestations of the disease in newborns, and its mechanism are not well characterized. STUDY DESIGN AND METHODS:A literature review identified 2...

journal_title：Transfusion

authors： Ohto H,Anderson KC

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:This randomized controlled study was undertaken to determine the effect of recombinant human erythropoietin (rHuEPO) on erythropoiesis, autologous blood collection, and allogeneic transfusion risk in elective surgery patients with low baseline hematocrits. STUDY DESIGN AND METHODS:Patients (n = 204) with lo...

journal_title：Transfusion

authors： Price TH,Goodnough LT,Vogler WR,Sacher RA,Hellman RM,Johnston MF,Bolgiano DC,Abels RI

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:JMH is a high-frequency red cell blood group antigen that resides on a 76- to 80-kDa glycosylphosphatidylinositol-linked protein also known as CDw108. Antibodies with JMH specificity are often autoimmune and are usually, if not always, clinically benign. Some individuals with JMH-variant antigen produce allo...

journal_title：Transfusion

authors： Mudad R,Rao N,Issitt PD,Roy RB,Combs MR,Telen MJ

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:When bacteria are found, after a platelet transfusion, in the recipient's blood as well as in the platelet concentrate (PC), a causal relationship is normally suspected, with the PC as the causative agent. The other alternative, that the patient has bacteremia and contaminated the PC, is less well documented...

journal_title：Transfusion

authors： Engstrand M,Engstrand L,Högman CF,Hambraeus A,Branth S

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Epitopes of blood group A antigen can be enzymatically cleaved from red cells (RBCs), but the extent of cleavage required for normal survival in allogeneic blood transfusion recipients is unknown. Therefore, the cleavage rates were studied for A antigen epitope binding of 1) complement-activating anti-A, 2) ...

journal_title：Transfusion

authors： Hoskins LC,Larson G,Naff GB

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:The rare Bombay phenotype is usually due to a primary genetic defect in an alpha-2- or alpha-4-fucosyltransferase. The present study was done to investigate a patient with normal transferases, who exhibits the Bombay phenotype. CASE REPORT:Red cells of the patient, his parents, and siblings were phenotyped ...

journal_title：Transfusion

authors： Shechter Y,Etzioni A,Levene C,Greenwell P

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Transfusion-associated Chagas' disease (TA-CD) is a worldwide problem. Measures adopted to prevent TA-CD include the clinical and serologic screening of blood donors and/or the inactivation of Trypanosoma cruzi present in collected blood, using gentian violet as the trypanocidal agent. This study investigate...

journal_title：Transfusion

authors： Moraes-Souza H,Bordin JO,Bardossy L,MacPherson DW,Blajchman MA

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Fc gamma RIIIb deficiency is a rare defect in which neutrophils do not express Fc gamma RIIIb and therefore the individuals with this defect have an NA null phenotype. Soluble Fc gamma RIII in plasma is severely decreased and almost undetectable. During pregnancy, Fc gamma RIIIb deficiency may cause the form...

journal_title：Transfusion

authors： Puig N,de Haas M,Kleijer M,Montoro JA,Pérez A,Villalba JV,Gomez I,von dem Borne AE

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:The Le(a) and Le(b) antigens are synthesized by cells making exocrine secretions, but it is not well-defined where plasma and red cell Le(a) and Le(b) antigens are made. STUDY DESIGN AND METHODS:This study uses chromatographic and immunochemical methods to extract Le(a) and Le(b) glycolipids from human tiss...

journal_title：Transfusion

authors： Hauser R

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Mobilized blood progenitor cells rapidly reconstitute hematopoiesis in patients after dose-intensive chemotherapy. However, optimal timing and methods of mobilized blood progenitor cell collection have yet to be fully defined. STUDY DESIGN AND METHODS:The utility of large-volume leukapheresis (LVL; > 15 L b...

journal_title：Transfusion

authors： Comenzo RL,Vosburgh E,Weintraub LR,Tansan S,Arkin CF,Wright DG

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Hypericin is a potent virucidal agent with activity against a broad range of enveloped viruses and retroviruses. The effective virucidal activity emanates from a combination of photodynamic and lipophilic properties. Hypericin binds cell membranes (and, by inference, virus membranes) and crosslinks virus cap...

journal_title：Transfusion

authors： Lavie G,Mazur Y,Lavie D,Prince AM,Pascual D,Liebes L,Levin B,Meruelo D

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Recovery and half-life estimations were carried out to compare a high-purity factor IX concentrate with an established factor IX complex concentrate. STUDY DESIGN AND METHODS:Two high-purity factor IX concentrates, which are identical except for the presence or absence of heparin (Immuninehep-plus and Immun...

journal_title：Transfusion

authors： Poon MC,Aledort LM,Anderle K,Kunschak M,Morfini M

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Little is known about the prevalence of and risk factors for human T-lymphotropic virus type I and type II (HTLV-I, HTLV-II) infections in Brazil. STUDY DESIGN AND METHODS:Sera from 17,063 healthy Brazilian donors were screened by enzyme-linked immunosorbent assay for antibody to HTLV-I/II between August 19...

journal_title：Transfusion

authors： Ferreira Júnior OC,Vaz RS,Carvalho MB,Guerra C,Fabron AL,Rosemblit J,Hamerschlak N

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Proinflammatory cytokines were measured in the supernatant portion of stored, bacterially contaminated, and/or white cell (WBC)-reduced units of red cells (RBCs). Previous studies from this laboratory and others have shown that cytokines are generated in platelet concentrates during storage. This earlier wor...

journal_title：Transfusion

authors： Stack G,Baril L,Napychank P,Snyder EL

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Donor white cells (WBCs) in blood transfusions are responsible for complications in recipients, including alloimmunization, graft-versus-host disease (GVHD), and virus transmission and reactivation. The recent use of sequence-specific polymerase chain reaction assays to monitor the kinetics of clearance of d...

journal_title：Transfusion

authors： Goodarzi MO,Lee TH,Pallavicini MG,Donegan EA,Busch MP

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:A new citrate-acetate-NaCl platelet additive solution, identified as PAS 2, was developed to prepare platelet concentrates (PCs) from pooled 0.5 CPD buffy coats (BCs). STUDY DESIGN AND METHODS:A study was undertaken to evaluate PAS 2 in vitro (n = 8) and in vivo (n = 9) against a commercially available solu...

journal_title：Transfusion

authors： van Rhenen DJ,Vermeij H,Kappers-Klunne M,Payrat JM

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:The preparation of platelet concentrates (PCs) from buffy coats (BCs) stored at room temperature is controversial, because of the strong metabolic activity of cells in BCs and the possible detrimental effect of neutrophil enzymes on platelets when the holding time before separation is prolonged. Despite good...

journal_title：Transfusion

authors： Boeri N,Saleun S,Pelissier E,Saleun JP,Aiach M,Rendu F

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Eleven laboratories participated in a study investigating whether swirling can be used in monitoring platelet discoid morphology in platelet concentrates (PCs). STUDY DESIGN AND METHODS:In each laboratory, two readers observed the swirling pattern in 1- to 5-day-old PCs, in PCs containing spherical platelet...

journal_title：Transfusion

authors： Bertolini F,Murphy S

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Since screening for antibody to hepatitis C virus (HCV) was introduced in 1990, posttransfusion hepatitis has been reduced to nearly background levels. This has led to reconsideration of the value of testing donated blood for elevated alanine aminotransferase (ALT). The contribution of ALT testing in detecti...

journal_title：Transfusion

authors： Sankary TM,Yang G,Romeo JM,Ulrich PP,Busch MP,Rawal BD,Vyas GN

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Currently, donors may arrive at blood collection sites without prior knowledge of eligibility and deferral criteria. STUDY DESIGN AND METHODS:The effects of distributing newly developed recruitment brochures 2 weeks in advance of blood drives and the provision of brochures on temporary deferral at the takin...

journal_title：Transfusion

authors： Gimble JG,Kline L,Makris N,Muenz LR,Friedman LI

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Mild cases of hemolytic disease of the newborn were being studied when it was recognized that the propositi's red cells carried a novel antigen. STUDY DESIGN AND METHODS:Serologic and genetic studies of a new low-incidence antigen, LOCR (International Society of Blood Transfusion series number 700.53), were...

journal_title：Transfusion

authors： Coghlan G,McCreary J,Underwood V,Zelinski T

更新日期：1994-06-01 00:00:00

abstract：:Hospitals are required by accrediting agencies to perform blood utilization review. Specific areas that must be addressed are the ordering, distribution, handling, dispensing, and administration of blood components. Monitoring the effects of transfusion on patients is also required. The format of the review process an...

journal_title：Transfusion

authors： Stehling L,Luban NL,Anderson KC,Sayers MH,Long A,Attar S,Leitman SF,Gould SA,Kruskall MS,Goodnough LT

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:As clinical diagnosis of heparin-associated thrombocytopenia (HAT) is often difficult, confirmation by sensitive laboratory assays is desirable. STUDY DESIGN AND METHODS:The sensitivity of the heparin-induced platelet activation (HIPA) test and the platelet aggregation test (PAT) was prospectively compared ...

journal_title：Transfusion

authors： Greinacher A,Amiral J,Dummel V,Vissac A,Kiefel V,Mueller-Eckhardt C

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Intracellular glutathione declines progressively in platelet concentrates stored for transfusion, but little is known about the nature of this process. STUDY DESIGN AND METHODS:Acivicin, an irreversible inhibitor of gamma-glutamyl transpeptidase, was used to determine the fate of glutathione lost from plate...

journal_title：Transfusion

authors： Burch PT,Aman M,Burch JW

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate an iodine-based method of activating potentially harmful viruses that might be found in normal human plasma. STUDY DESIGN AND METHODS:A procedure has been developed for inactivating lipid-enveloped and non-lipid-enveloped model viruses in normal human plasma by usin...

journal_title：Transfusion

authors： Highsmith FA,Xue H,Caple M,Walthall B,Drohan WN,Shanbrom E

更新日期：1994-04-01 00:00:00